A New Model for Phenotypic Suppression of Frameshift Mutations by Mutant tRNAs
نویسندگان
چکیده
منابع مشابه
A new model for phenotypic suppression of frameshift mutations by mutant tRNAs.
According to the prevailing model, frameshift-suppressing tRNAs with an extra nucleotide in the anticodon loop suppress +1 frameshift mutations by recognizing a four-base codon and promoting quadruplet translocation. We present three sets of experiments that suggest a general alternative to this model. First, base modification should actually block such a four-base interaction by two classical ...
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ژورنال
عنوان ژورنال: Molecular Cell
سال: 1998
ISSN: 1097-2765
DOI: 10.1016/s1097-2765(00)80048-9